bianco lab

Selected papers 1998-2008

1.    Bianco P, Kuznetsov S, Riminucci M, Fisher LW, Spiegel AM, Gehron Robey P: Reproduction of human fibrous dysplasia of bone in immunocompromised mice by transplanted mosaics of normal and Gsα-mutated skeletal progenitor cells. Journal of Clinical Investigation  101: 1737-1744, 1998

2.    Xu T, Bianco P, Fisher LW, Longenecker G, Boskey A, Smith E, Goldstein S, Bonadio J, Zhao C, Dominguez P, Heegard AM, Satomura K, Gehron Robey P, Kulkarni A, Sommer B, Young MF: Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice. Nature Genetics 20: 78-82, 1998

3.    Holmbeck K,  Bianco P, Caterina J, Yamada S, Kromer M, Kuznetsov SA, Mankani M, Gehron Robey P, Poole AR, Pidoux  I,   Ward  J,    Birkedal–Hansen H: MT1-MMP deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover.  Cell  99: 81-92, 1999

4.    Bianco P, Gehron Robey P: Marrow stromal stem cells. Journal of Clinical Investigation, 105: 1663-1668, 2000

5.    Kuznetsov SA, Mankani M, Gronthos S, Satomura K, Bianco P, Robey PG. Circulating skeletal stem cells. Journal of Cell Biology 153:1133-1139, 2001

6.    Bianco P, Gehron Robey P: Stem cells in tissue engineering. Nature 414: 118-121, 2001

7.    Jiménez MJG, Balbín M, Alvarez J, Komori T, Bianco P, Holmbeck K, Birkedal-Hansen H, López JM, López-Otín C. A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formation.  Journal of Cell Biology 155: 1333-1344, 2001

8.    Minasi MG, Riminucci M, De Angelis L, Borello U, Berarducci B, Innocenzi A, Caprioli A, Sirabella D, Baiocchi M, De Maria R, Boratto R, Jaffredo T, Broccoli V, Bianco P, Cossu G: The Meso-Angioblast: A Multipotent, Self-Renewing Cell, That Originates From The Dorsal Aorta And Differentiates Into Mesodermal Tissues. Development 129: 2773-2783, 2002

9.    Holmbeck K, Bianco P, Birkedal-Hansen H: MT1-MMP: a collagenase essential for tumor cell invasive growth. Cancer Cell, 4: 83-84, 2003

10.    Riminucci M, Collins MT, Fedarko S, Cherman N, Corsi A, White KE, Waguespack S, Gupta A, Hannon T,  Econs MJ, Bianco P,  and Gehron Robey P : Fibroblast Growth Factor-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting.  Journal of Clinical Investigation 112: 683-692, 2003

11.    Cattelino A, Liebner S, Zanetti A, Gallini R, Balconi G, Corsi A,   Bianco P,   Wolburg H, Moore R,   Oreda B,   Kemler R and Dejana E: The conditional inactivation of -catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. Journal of Cell Biology 162: 1111-1122, 2003

12.    Cossu G, Bianco P: Mesoangioblasts. Vascular progenitors for extravascular mesodermal tissues. Currrent Opinions in Genetics and Development 13:537-542, 2003

13.    Holmbeck K, Bianco P, Yamada S, Chrysovergis K Birkedal-Hansen H: MT1-MMP dependent, apoptotic remodeling of unmineralized cartilage: a critical process in skeletal growth. Journal of Cell Biology 163:661-671, 2003

14.    Kuznetsov SA, Riminucci M, Ziran N, Tsutsui TW, Corsi A, Calvi L, Kronenberg HM, Schipani E, Gehron Robey P, Bianco P: The interplay of osteogenesis and hematopoiesis:  Expression of a constitutively active PTH/PTHrP receptor in osteogenic cells perturbs the establishment of hematopoiesis in bone and of skeletal stem cells in the bone marrow. Journal of Cell Biology 167:1113-1122, 2004

15.    Dellavalle, A, Sampaolesi, M, Tonlorenzi, R,  Tagliafico, E,  Sacchetti, B,  Perani, L,, Innocenzi, B,  Galvez, BG,  Messina, G,   Morosetti, R,  Li, S,  Belicchi, M,  Peretti, G,  Chamberlain, JS,  Wright, WE,  Torrente, Y,   Ferrari, S,   Bianco, P and Cossu, G. Pericytes of human post-natal skeletal muscle are myogenic precursors, distinct from satellite cells, and efficiently repair dystrophic muscle. Nature Cell Biology 9: 255-267, 2007

16.    Mosig RA, Bowling O, DiFeo A, Ramirez MCM, Parker IC, Abe E, Diouri J, Al Aqeel A, Wylie JW,. Oblander SA, Madri J, Bianco P, Apte SS, Zaidi M, Doty SB,  Majeska RJ, Schaffler MB, Martignetti JA: Loss of MMP-2 disrupts skeletal and craniofacial development, and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth. Human Molecular Genetics, 16: 1113-1123, 2007

17.    Heegaard AM , Corsi A, Danielsen CC, Nielsen KL, Riminucci M, Young MF, Bianco P. Biglycan deficiency causes spontaneous aortic dissection and rupture in mice. Circulation 115: 2687-2688, 2007  

18.    Michienzi S, Cherman N, Holmbeck K, Funari A, Collins MT, Bianco P, Gehron Robey P, Riminucci M: GNAS transcripts in skeletal progenitors:  Evidence for random asymmetric allelic expression of Gsa. Human Molecular Genetics16:1921-1930, 2007

19.    Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, Saggio I, Tagliafico E, Ferrari S, Gehron Robey P, Riminucci M, Bianco P: Self-renewing osteoprogenitors in bone marrow sinusoids can organize the hematopoietic microenvironment.  Cell 131: 324-336, 2007

20.    Bianco P, Gehron Robey P, Simmons P: Mesenchymal stem cells: revisiting history, concepts and assays. CellStemCell 2:313-319, 2008